PulsHeart: IHU Liryc Start-up

Dr. Nademanee is an internationally recognized electrophysiologist. He is a Distinguished Professor of Medicine at Chulalongkorn University, Thailand, and Director of the Center of Excellence in Arrhythmia Research at Chulalongkorn University, as well as the Heart Institute at Bumrungrad International Hospital. He received an honorary Doctor of Medicine degree from Mahidol University and was appointed a Knight Grand Commander of the Most Illustrious Order of Chula Chom Klao, a prestigious Royal Thai decoration conferred by King Bhumibol Adulyadej. His clinical and research work focuses on atrial fibrillation, ventricular arrhythmias, electrical storm management, and catheter ablation therapies. He has authored numerous influential peer-reviewed publications, including seminal work on electrical storm treatment, arrhythmogenic substrate ablation in J-wave syndromes, and electrogram-guided ablation strategies for atrial fibrillation. He was the first to identify the right ventricular epicardium—particularly the right ventricular outflow tract (RVOT)—as a key arrhythmogenic substrate in Brugada syndrome. He continues to lead and publish clinical studies, including investigations of catheter ablation for Brugada syndrome and refractory ventricular tachycardia.

Charu Ramanathan is a medical technology entrepreneur and biomedical engineering inventor, whose doctoral work led to the clinical translation of non-invasive electrocardiographic imaging (ECGI). She co-founded CardioInsight, the company behind high-density non-invasive cardiac mapping systems, which was acquired by Medtronic in 2015. Holder of a PhD in biomedical engineering from Case Western Reserve University, she has since founded and advised several digital health and MedTech companies, including Vitalxchange. She continues to bridge advanced technical research, product strategy, and clinical adoption, actively contributing to the evolution of medical innovation.

Rémi Dubois is a professor and senior researcher at IHU Liryc (Electrophysiology & Heart Modelling Institute, Bordeaux), where he leads the Signal Processing team and co-leads the Connected Health department. His work lies at the interface between instrumentation, biomedical signal processing, and non-invasive cardiac mapping. He develops tools to extract and localize electrical activity from surface recordings to better understand and treat cardiac arrhythmias. He is author or co-author of over 200 peer-reviewed scientific publications and regularly contributes to translational projects and training programs conducted by IHU Liryc.

Olivier Bernus is a professor at the University of Bordeaux, current Scientific Director of IHU Liryc (Institute for Cardiac Rhythm Diseases), and head of the Cardiac Electrophysiology team at the Bordeaux Cardio-Thoracic Research Center (CRCTB U1045). His work combines experimental optical mapping, computational cardiac modeling, and high-resolution imaging to study the mechanisms of arrhythmias, ventricular fibrillation and sudden cardiac death, and translate these insights into diagnostic and therapeutic innovations. He is co-author of over 150 scientific publications and has coordinated several major projects, both nationally and internationally. He is currently involved in various translational research projects and training programs, and regularly contributes to international conferences on arrhythmias.

Dr. Karim Benali is a cardiac electrophysiologist based at Saint-Étienne University Hospital, actively collaborating on clinical and research work with IHU Liryc / Hôpital Haut-Lévêque (Bordeaux). His clinical activity focuses on ventricular arrhythmias, electrical storm management, and advanced ablation therapies. He also participates in research on sudden cardiac death and idiopathic ventricular fibrillation. He is author and co-author of numerous articles published in peer-reviewed journals and regularly speaks at international conferences on cardiac rhythm disorders.