{"id":749,"date":"2023-10-05T19:16:00","date_gmt":"2023-10-05T17:16:00","guid":{"rendered":"https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/"},"modified":"2025-12-16T08:32:16","modified_gmt":"2025-12-16T07:32:16","slug":"left-ventricular-abnormal-substrate-in-brugada-syndrome","status":"publish","type":"science","link":"https:\/\/pulsheart-medical.com\/en\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/","title":{"rendered":"Left Ventricular Abnormal Substrate in Brugada Syndrome"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p><strong>Background:<\/strong> Slow-conductive structural abnormalities located in the epicardium of the right ventricle underlie Brugada syndrome. This investigation examined whether similar substrate extends to the left ventricle (LV).<\/p>\n\n\n\n<p><strong>Methods and Results:<\/strong> Study population consisted of 22 patients (mean age 46 \u00b1 11 years, predominantly male) experiencing recurrent ventricular arrhythmias. High-density biventricular epicardial mapping identified abnormal substrate in all participants&#8217; right ventricular epicardium (27 \u00b1 11 cm\u00b2) and in 45% of cases on the LV epicardium.<\/p>\n\n\n\n<p>Key findings revealed that LV substrate patients exhibited longer arrhythmia histories, prolonged cardiac intervals, and higher rates of SCN5A mutations (70% versus 25%). Those with SCN5A mutations demonstrated elevated polygenic risk scores compared to unselected populations.<\/p>\n\n\n\n<p><strong>Conclusion:<\/strong> A subset of patients with Brugada syndrome present an abnormal substrate extending onto the LV epicardium and inferior RV that is associated with SCN5A mutations and multigenic variants.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Publication Information<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Journal:<\/strong> JACC Clinical Electrophysiology<\/li>\n<li><strong>Volume:<\/strong> 9, Issue 10<\/li>\n<li><strong>Pages:<\/strong> 2041-2051<\/li>\n<li><strong>Publication Date:<\/strong> October 2023<\/li>\n<li><strong>DOI:<\/strong> 10.1016\/j.jacep.2023.05.039<\/li>\n<li><strong>PMID:<\/strong> 37480873<\/li>\n<li><strong>PubMed Link:<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37480873\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37480873\/<\/a><\/li>\n<li><strong>JACC Link:<\/strong> <a href=\"https:\/\/www.jacc.org\/doi\/10.1016\/j.jacep.2023.05.039\" target=\"_blank\" rel=\"noopener\">https:\/\/www.jacc.org\/doi\/10.1016\/j.jacep.2023.05.039<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Authors<\/h3>\n\n\n\n<p>Ghassen Cheniti, Michel Haissaguerre, Christian Dina, Tsukasa Kamakura, Josselin Duchateau, Frederic Sacher, Hugo-Pierre Racine, Elodie Surget, Floriane Simonet, Jean-Baptiste Gourraud, Soumaya Sridi, Hubert Cochet, Clementine Andre, Benjamin Bouyer, Remi Chauvel, Romain Tixier, Nicolas Derval, Thomas Pambrun, Remi Dubois, Pierre Jais, Koonlawee Nademanee, Richard Redon, Jean-Jacques Schott, Vincent Probst, Meleze Hocini, Julien Barc, Olivier Bernus<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Published in: JACC Clinical Electrophysiology (October 2023)<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"science_category":[34],"class_list":["post-749","science","type-science","status-publish","hentry","science_category-pulsheart-ihu-lyric"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publications Scientifiques en Cardiologie | PulsHeart<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez les publications scientifiques s\u00e9lectionn\u00e9es par PulsHeart en cardiologie, recherche m\u00e9dicale et innovation. Ressources acad\u00e9miques de r\u00e9f\u00e9rence.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications Scientifiques en Cardiologie | PulsHeart\" \/>\n<meta property=\"og:description\" content=\"D\u00e9couvrez les publications scientifiques s\u00e9lectionn\u00e9es par PulsHeart en cardiologie, recherche m\u00e9dicale et innovation. Ressources acad\u00e9miques de r\u00e9f\u00e9rence.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"Pulsheart\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-16T07:32:16+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pulsheart-medical.com\\\/science\\\/left-ventricular-abnormal-substrate-in-brugada-syndrome\\\/\",\"url\":\"https:\\\/\\\/pulsheart-medical.com\\\/science\\\/left-ventricular-abnormal-substrate-in-brugada-syndrome\\\/\",\"name\":\"Publications Scientifiques en Cardiologie | PulsHeart\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pulsheart-medical.com\\\/#website\"},\"datePublished\":\"2023-10-05T17:16:00+00:00\",\"dateModified\":\"2025-12-16T07:32:16+00:00\",\"description\":\"D\u00e9couvrez les publications scientifiques s\u00e9lectionn\u00e9es par PulsHeart en cardiologie, recherche m\u00e9dicale et innovation. Ressources acad\u00e9miques de r\u00e9f\u00e9rence.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pulsheart-medical.com\\\/science\\\/left-ventricular-abnormal-substrate-in-brugada-syndrome\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pulsheart-medical.com\\\/science\\\/left-ventricular-abnormal-substrate-in-brugada-syndrome\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pulsheart-medical.com\\\/science\\\/left-ventricular-abnormal-substrate-in-brugada-syndrome\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/pulsheart-medical.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Science\",\"item\":\"https:\\\/\\\/pulsheart-medical.com\\\/science\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Left Ventricular Abnormal Substrate in Brugada Syndrome\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pulsheart-medical.com\\\/#website\",\"url\":\"https:\\\/\\\/pulsheart-medical.com\\\/\",\"name\":\"Pulsheart\",\"description\":\"Pr\u00e9venir la mort subite. Sauver des Vies.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pulsheart-medical.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Publications Scientifiques en Cardiologie | PulsHeart","description":"D\u00e9couvrez les publications scientifiques s\u00e9lectionn\u00e9es par PulsHeart en cardiologie, recherche m\u00e9dicale et innovation. Ressources acad\u00e9miques de r\u00e9f\u00e9rence.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/","og_locale":"en_US","og_type":"article","og_title":"Publications Scientifiques en Cardiologie | PulsHeart","og_description":"D\u00e9couvrez les publications scientifiques s\u00e9lectionn\u00e9es par PulsHeart en cardiologie, recherche m\u00e9dicale et innovation. Ressources acad\u00e9miques de r\u00e9f\u00e9rence.","og_url":"https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/","og_site_name":"Pulsheart","article_modified_time":"2025-12-16T07:32:16+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/","url":"https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/","name":"Publications Scientifiques en Cardiologie | PulsHeart","isPartOf":{"@id":"https:\/\/pulsheart-medical.com\/#website"},"datePublished":"2023-10-05T17:16:00+00:00","dateModified":"2025-12-16T07:32:16+00:00","description":"D\u00e9couvrez les publications scientifiques s\u00e9lectionn\u00e9es par PulsHeart en cardiologie, recherche m\u00e9dicale et innovation. Ressources acad\u00e9miques de r\u00e9f\u00e9rence.","breadcrumb":{"@id":"https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/pulsheart-medical.com\/science\/left-ventricular-abnormal-substrate-in-brugada-syndrome\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/pulsheart-medical.com\/en\/"},{"@type":"ListItem","position":2,"name":"Science","item":"https:\/\/pulsheart-medical.com\/science\/"},{"@type":"ListItem","position":3,"name":"Left Ventricular Abnormal Substrate in Brugada Syndrome"}]},{"@type":"WebSite","@id":"https:\/\/pulsheart-medical.com\/#website","url":"https:\/\/pulsheart-medical.com\/","name":"Pulsheart","description":"Pr\u00e9venir la mort subite. Sauver des Vies.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pulsheart-medical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/pulsheart-medical.com\/en\/wp-json\/wp\/v2\/science\/749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pulsheart-medical.com\/en\/wp-json\/wp\/v2\/science"}],"about":[{"href":"https:\/\/pulsheart-medical.com\/en\/wp-json\/wp\/v2\/types\/science"}],"wp:attachment":[{"href":"https:\/\/pulsheart-medical.com\/en\/wp-json\/wp\/v2\/media?parent=749"}],"wp:term":[{"taxonomy":"science_category","embeddable":true,"href":"https:\/\/pulsheart-medical.com\/en\/wp-json\/wp\/v2\/science_category?post=749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}