{"id":761,"date":"2025-05-30T18:25:32","date_gmt":"2025-05-30T16:25:32","guid":{"rendered":"https:\/\/pulsheart-medical.com\/science\/origin-of-ventricular-fibrillation-triggers-in-a-model-of-localized-repolarization-heterogeneity\/"},"modified":"2025-12-16T08:29:31","modified_gmt":"2025-12-16T07:29:31","slug":"origin-of-ventricular-fibrillation-triggers-in-a-model-of-localized-repolarization-heterogeneity","status":"publish","type":"science","link":"https:\/\/pulsheart-medical.com\/en\/science\/origin-of-ventricular-fibrillation-triggers-in-a-model-of-localized-repolarization-heterogeneity\/","title":{"rendered":"Origin of ventricular fibrillation triggers in a model of localized repolarization heterogeneity"},"content":{"rendered":"\n

Authors:<\/strong> Estelle Renard, Michel Ha\u00efssaguerre, Laura R Bear, Olivier Bernus<\/p>\n\n\n\n

Published in:<\/strong> Heart Rhythm, Volume 22, Issue 5, Pages 1345-1354 (May 2025)<\/p>\n\n\n\n

Publication Date:<\/strong> Published online October 21, 2024<\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background:<\/strong> Repolarization variations contribute to ventricular fibrillation (VF) initiation.<\/p>\n\n\n\n

Objective:<\/strong> To examine how repolarization heterogeneity leads to VF triggers.<\/p>\n\n\n\n

Methods:<\/strong> Using isolated porcine hearts with localized repolarization heterogeneity induced by pinacidil, researchers performed optical mapping and electrocardiography.<\/p>\n\n\n\n

Results:<\/strong> The study showed 74 VF episodes in 13 hearts (82%), triggered by premature ventricular complexes with brief coupling intervals (297 \u00b1 66 ms). All 16 optically mapped VF initiations originated from border zones between altered and normal repolarization areas, where action potential duration and repolarization time gradients were significantly steeper.<\/p>\n\n\n\n

Conclusion:<\/strong> Findings indicate VF triggers consistently emerge from repolarization dispersion boundaries, suggesting phase 2 reexcitation mechanisms.<\/p>\n\n\n\n

Links:<\/strong>
\n\u2022 PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/39442641\/<\/a>
\n\u2022 DOI: 10.1016\/j.hrthm.2024.10.027<\/a>
\n\u2022 PMCID: PMC12048301<\/p>\n","protected":false},"excerpt":{"rendered":"

Published in: Heart Rhythm, Volume 22, Issue 5, Pages 1345-1354 (May 2025)<\/p>\n","protected":false},"featured_media":0,"template":"","meta":[],"science_category":[],"class_list":["post-761","science","type-science","status-publish","hentry"],"yoast_head":"\nPublications Scientifiques en Cardiologie | PulsHeart<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez les publications scientifiques s\u00e9lectionn\u00e9es par PulsHeart en cardiologie, recherche m\u00e9dicale et innovation. 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